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发布于:2020-11-27 09:20:24  访问:0 次 回复:0 篇
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Sporn and colleagues found a substantial loss of grey matter through the teenage years in patients with earlyonset schizophrenia.years after the first hospitalization in patients with schizophrenia.However, these researchers did not find further deterioration over a year period.Taken together, these studies indicate fairly comprehensive, multifocal structural changes in the brain over time in patients with firstepisode psychosis.Progressive volume loss seems most pronounced in the frontal and temporal areas.Progressive brain tissue loss in schizophrenia is, during a year period, found to be approximately twice that found in healthy people because of normal aging. Rather, in general, there seems to be some improvement in neurocognitive functioning, at least during the first period after the patients have gone into remission. It was concluded that after the onset of illness, neurocognitive functioning is relatively stable over time.They show the same improvement in neurocognitive functioning that has been found in a number of studies the first years after the onset of illness.However, after years, the Targetmol‘s Methylprednisolone upward curve flattens out, and after years, the patients perform at the same level as they did at the first assessment.Two studies with a year followup time found no further reduction in neurocognitive functions over the first years in patients that were assessed the first time at the onset of illness.However, they showed less improvement after years than healthy controls on specific functions when controlling for differences between the groups at the first assessment.Hoff and colleagues concluded that patients remain relatively stable with regard to their level of neurocognitive functioning, at least through the first years after the onset of illness.Finally, these finding are confirmed and strengthened by a recent report from ie and collaborators. She NORD J PSYCHIATRY VOL NO has followed a group of earlyonset schizophrenia over a year period; a longer followup than in any other study.Beyond this general pattern of stability over the first years after illness onset, there is probably a certain fluctuation in level of functioning, particularly in functions that are state related investigated patients with schizophrenia with a battery consisting of neuropsychological tests in two distinct different phasesan acute phase and a remission phase.We found a clear tendency that patients performed better when they were in remission.This may indicate that the psychotic experiencessymptoms themselves make it more difficult to concentrate on the test, something which is necessary to perform well.It is difficult to know whether it is the fact that the psychotic symptoms disappear that makes the patient also perform better on neuropsychological tests, or whether the improvement is caused by other factors, such as for instance the direct chemical effect of medication.First of all, there is no evidence of gliosis in schizophrenia. Also, in post mortem studies, there is no consistent evidence of degenerated neurons, cellular changes, loss of cell embryos or molecular changes. A third argument against schizophrenia being a degenerative disorder is the fact that many patients show clinical improvement over time.This is, however, a more likely combination than performing as well on neuopsychological tests over time, while at the same time losing brain tissue.
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